Publications

Peer-reviewed papers published in reputable journals offer the most reliable and current research on a variety of medical topics. We have assembled a collection of publications for more information on pFOX inhibition and mitochondrial substrate replacement therapy.

pFOX inhibition – Mechanism

pFOX inhibition – Angina

pFOX inhibition – Heart Failure

Mitochondrial Substrate Replacement – Inborn Errors of Metabolism

pFOX inhibition


Myocardial fatty acid metabolism in health and disease

Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC.

Physiological Reviews. 2010 Jan;90(1):207-58. doi: 10.1152/physrev.00015.2009.


The failing heart–an engine out of fuel

Neubauer S.

New England Journal of Medicine. 2007 Mar 15;356(11):1140-51.


Trimetazidine: a meta-analysis of randomised controlled trials in heart failure

Gao D, Ning N, Niu X, Hao G, Meng Z.

Heart. 2011 Feb;97(4):278-86. doi: 10.1136/hrt.2010.208751. Epub 2010 Dec 5.


Mitochondrial substrate replacement therapy


Anaplerotic therapy in propionic acidemia

Longo N, Price LB, Gappmaier E, Cantor NL, Ernst SL, Bailey C, Pasquali M.

Molecular Genetics and Metabolism. 2017 Sep;122(1-2):51-59. doi: 10.1016/j.ymgme.2017.07.003. Epub 2017 Jul 12.


Triheptanoin versus trioctanoin for long-chain fatty acid oxidation disorders: a double blinded, randomized controlled trial

Gillingham MB, Heitner SB, Martin J, Rose S, Goldstein A, El-Gharbawy AH, Deward S, Lasarev MR, Pollaro J, DeLany JP, Burchill LJ, Goodpaster B, Shoemaker J, Matern D, Harding CO, Vockley J.

Journal of Inherited Metabolic Disease. 2017 Nov;40(6):831-843. doi: 10.1007/s10545-017-0085-8. Epub 2017 Sep 4.


Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency

Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E.

Nature Communications. 2016 Aug 9;7:12317. doi: 10.1038/ncomms12317.