Heart Failure

Heart Failure is a chronic, progressive condition in which the heart is unable to keep up with its workload and may not adequately deliver blood throughout the body. Routine daily activities can become exhausting and strenuous as the heart struggles to keep up with energy demands.

A heart’s job is to continuously pump blood throughout the body. The left side of the heart pumps oxygen rich blood to the body’s tissues and organs.  The right side of the heart sends blood to the lungs, where it’s infused with oxygen.

Heart failure is a serious condition, and there’s usually no cure. There are two primary types of heart failure:

  • Heart failure with reduced ejection fraction (HFrEF): The heart can’t pump with enough force to adequately circulate blood throughout the body.
  • Heart failure with preserved ejection fraction (HFpEF): The heart becomes rigid and can’t properly fill with blood.

People living with heart failure may experience a variety of symptoms including shortness of breath, fatigue, increased heart rate, and an inability to tolerate exercise.

An estimated 26 million people worldwide, and 6.5 million Americans, suffer from heart failure, with about half having HFrEF. In the United States, nearly 1 in 3 Americans living with heart failure are hospitalized every year.

The Imbria Solution

Imbria is developing IMB-101 as a potential treatment for heart failure. IMB-101 is designed to improve blood flow by increasing the efficiency of energy production in the heart so it can carry a more normal workload. This approach is different than the current standards of care, which are focused on reducing the heart’s workload. We believe that more efficient energy production will improve the ability of the heart to pump blood throughout the body.