Our approach at Imbria is to improve the heart’s ability to manufacture the energy it needs so that it can maintain a more normal workload.
Under normal circumstances, a mix of both sugars (glucose) and fats (fatty acids) provides fuel for cardiac cells to create energy. This cellular metabolism is crucial to generating the energy required for the heart to pump effectively.
When blood flow is reduced and oxygen levels available to heart cells are lower than usual, as in patients with refractory angina, the use of fats for energy increases but this is an inefficient process since in these conditions, heart cells may need 10-to-15% more oxygen to generate the same amount of energy from fat versus from sugar. With fat as a primary energy source in a reduced oxygen environment, less energy is generated per molecule of oxygen resulting in a less oxygen efficient contraction of the heart muscle.