nHCM

Hypertrophic cardiomyopathy (HCM) is a genetic disease where the heart’s main pumping chambers, the ventricles, become abnormally thickened. HCM can affect people of any age, but it is more likely as age increases. It is most often diagnosed in middle age, and symptoms can vary widely.

One of the key issues in HCM is a deficiency in cardiac energy, resulting from increased energy demands during contraction, and inefficient energy utilization by the cardiac muscle. This energy deficiency has a significant impact on the functioning of the heart, impairing the relaxation and filling of the heart, and leading to symptoms such as breathlessness and reduced exercise capacity. Impaired energetics occurs early in the progression of HCM, even before the development of heart muscle thickening.