New investor AXA IM Alts joins upsized Series B round to support clinical advancement and expand global health impact of ninerafaxstat, a novel cardiovascular therapeutic

Dr. Zina Affas Besse (AXA IM Alts) and Mr. Ken Horne (AN Ventures) appointed to Imbria Board of Directors

BOSTON, Mass., November 17, 2025 — Imbria Pharmaceuticals, Inc. (“Imbria”), a clinical-stage company developing transformational cardiovascular disease therapeutics, today announced the participation of AXA IM Alts in an upsized Series B financing, advancing the company’s mission to develop breakthrough solutions that address the world’s most urgent cardiovascular health challenges. With this investment, AXA IM Alts joins a leading investor syndicate that includes RA Capital, SV Health Investors, Deep Track Capital, AN Ventures, Catalio Capital Management, and Cytokinetics, Inc. 

Proceeds from the financing will support the continued clinical development of ninerafaxstat, Imbria’s differentiated, first-in-class therapy designed to improve cardiac energetics in patients with serious cardiovascular diseases. Cardiovascular disease remains the world’s leading cause of mortality, responsible for more than 20 million lives lost each year and representing one of the greatest global health and economic burdens in both the developed and developing world.

“The tremendous burden of cardiovascular disease demands bold innovation now,” said Alvin Shih, MD, Chief Executive Officer of Imbria Pharmaceuticals. “The extension of our Series B financing reflects strong investor confidence in Imbria’s scientific foundation, clinical execution, and the potential of ninerafaxstat to address the growing burden of cardiovascular diseases worldwide. We look forward to working with AXA IM Alts, a leader in global health investing committed to deploying capital toward solutions that address some of the world’s most urgent health challenges.”

As part of the financing, Zina Affas Besse, PhD, Partner and Deputy Head of Healthcare Private Equity of AXA IM Alts, has been appointed to Imbria’s Board of Directors. Dr. Affas Besse brings more than 25 years of healthcare venture capital and operating experience, including leadership roles at Atlas Venture, Orion Healthcare Equity Partners, and AXA IM Alts.

“Imbria’s potential to reshape the treatment of cardiovascular diseases globally is both timely and transformative,” said Dr. Zina Affas Besse. “At AXA IM Alts, we are committed to supporting innovations that deliver worldwide impact, and look forward to working with Imbria as they advance ninerafaxstat toward improving outcomes for patients who face limited options today.”

Imbria has also appointed Ken Horne, Managing Partner at AN Ventures, a participating investor in the Series B financing, to its Board of Directors. Mr. Horne is a seasoned healthcare investor, entrepreneur, and executive with over 20 years of experience founding, leading, and investing in life science companies.

“Cardiovascular disease is one of the most pressing healthcare challenges of our time, and innovation in this space has lagged far behind need,” said Mr. Horne. “AN Ventures is proud to partner with Imbria to fundamentally reshape the treatment landscape for patients and families who live with cardiovascular disorders.”

Imbria is advancing ninerafaxstat in the ongoing global, multicenter, FORTITUDE-HCM Phase 2b clinical trial (NCT07023614) in symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM), a debilitating disease with no currently approved treatments.